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Biochemical Society transactions Journal
Papers
Chimaeric antigen receptor (CAR) T-cells have shown impressive results in patients with B-cell leukaemia. Yet, in patients with lymphoma durable responses are still rare and heavy preconditioning required. Apoptosis resistance is considered a hallmark of cancer, often conveyed by...
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Autophagy is a lysosomal degradation system that involves de novo autophagosome formation. A lot of factors are involved in autophagosome formation, including dozens of Atg proteins that form supramolecular complexes, membrane structures including vesicles and organelles, and eve...
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Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were targeted to these secretory vesicles. When the cells were stimulated with nicotine 48 h after transduction, the fractional loss ...
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Conference Article| August 01 1995 Physiological signals and pathological mediators of lipid metabolism during lactation R. D. Evans R. D. Evans 1Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, U.K. Search for other ...
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Conference Article| February 01 1991 The development of insulin-dependent diabetes mellitus in non-obese diabetic mice: the role of CD4+ and CD8+ T cells Anne-Marie Varey; Anne-Marie Varey 1Department of Immunology, University College and Middlesex School of Medicine, Arthur Stan...
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While it is self-evident that all extracellular molecules are an integral part of a multicellular organism, it is paradoxical that they are often considered to be dissociated from cells. The reality is that a continuum of dynamic, bi-directional interactions links the intracellul...
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Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'-> 5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylatio...
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Conference Article| December 01 1984 Drug targeting to lysosomes RUTH DUNCAN; RUTH DUNCAN *Department of Biological Sciences, University of Keele, Keele, Staffs. ST5 5BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar JINDŘICH KOPEČEK; JINDŘICH KOP...
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Conference Article| February 01 1994 A Novel trypsin-like enzyme in breast cancer J. McIlroy; J. McIlroy 1Division of Biochemistry, The Queens University of Belfast, Medical Biology Centre, Lisburn Road, Belfast BT9 7BL Search for other works by this author on: This Site PubMed G...
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Conference Article| February 01 1984 Dynamics of the localization of drug metabolizing enzymes in tissues and cells C. R. WOLF; C. R. WOLF *Imperial Cancer Research Fund, Medical Oncology Unit, Western General Hospital, Edinburgh EH4 2XU, U.K. Search for other works by this autho...
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Conference Article| November 01 1991 Application of approach to equilbrium analytical ultracentrifugation (Archibald method) to the determination of molecular weights of humic substances ALAN E. WILKINSON; ALAN E. WILKINSON *Department of Biochemistry and Molecular Biology, Unive...
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Conference Abstract| November 01 1996 OXIDATIVE STRESS AND CELL DEATH DURING MOUSE DEVELOPMENT Luis Covarrubias; Luis Covarrubias 1Depto. de Genética y Fisiología Molecular, Instituto de Biotecnología, UNAM, Apdo. Postal 510-3, Cuemavaca, Mor. 62271, México Search for other works...
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