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    • Journal of the Canadian Association of Gastroenterology Journal

    Papers
    A63 THE COLONIC PATHOGEN, ENTAMOEBA HISTOLYTICA ACTIVATES CASPASE-4 IN HUMAN MACROPHAGES THAT CLEAVES GASDERMIN D TO FACILITATE IL-1β SECRETION IN THE ABSENCE OF CELL DEATH
    S Wang,F Moreau,K Chadee
    Journal of the Canadian Association of Gastroenterology（2022）
    Abstract Background A hallmark of Entamoeba histolytica ( Eh) invasion in the gut is acute intestinal inflammation dominated by the secretion of pro-inflammatory cytokines. Live Eh in contact with macrophages activates caspase-1 by the recruitment of the NLRP3 inflammasome in a G...
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    A37 exploring the proteomics differences in crohn’s disease patients
    L Nogueira de Almeida,B Mainoli, A K Filyk,S A Hirota,C Lu,A Dufour
    Journal of the Canadian Association of Gastroenterology（2021）
    Abstract Background Canada has the highest prevalence rate of Crohn’s disease (CD) in North America. In Alberta, the yearly cost of anti-inflammatory drugs can be more than $25,000 per person; however, half of the patients do not respond to medication. CD is characterized by lesi...
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    A139 A LOW FODMAP DIET REDUCES SYMPTOMS IN INDIVIDUAL IBS PATIENTS BUT NOT MUCOSAL IMMUNE ACTIVATION OF NOCICEPTORS
    S M Bennet,C J Tuck, N, Lopez,J O Jaramillo Polanco, C Morissette, S Rolland,P Bercik,D E Reed,S Vanner
    Journal of the Canadian Association of Gastroenterology（2019）
    Lowering dietary FODMAPs in IBS patients reduces symptom severity in many cases yet the mechanism is poorly understood. It has been proposed that FODMAPs may activate mast cells in some patients. Mast cell mediators in turn could sensitize nociceptors innervating the gut, leading...
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    A87 ACTIVATION OF NR4A1 REDUCES INFLAMMATION-ASSOCIATED INTESTINAL FIBROSIS AND DAMPENS FIBROGENIC SIGNALING IN INTESTINAL MYOFIBROBLASTS
    V P Venu,L Alston, H Szczepanski,S A Hirota
    Journal of the Canadian Association of Gastroenterology（2019）
    Intestinal fibrosis is a common complication of IBD, comprises of excessive accumulation of scar tissue in the intestinal wall. Fibrosis is thought to result from an aberrant response to injury resulting in excessive extracellular matrix (ECM) deposition, which can lead to tissue...
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    A271 GASTRIC METASTASES FROM PRIMARY BREAST CANCERS PRESENTING AS RARE CAUSES OF COMMON GASTROINTESTINAL DISORDERS
    T Yuen,E Y Liu,A R Kohansal
    Journal of the Canadian Association of Gastroenterology（2019）
    Breast cancer is the most common malignancy in women worldwide and contributes to high morbidity and mortality. Metastases to the gastrointestinal tract are rare and present with a wide variability clinically and endoscopically. We report 2 cases of gastric metastases from primar...
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    A8 DIETARY TRYPTOPHAN MODULATES KYNURENINE AND INDOLE PRODUCTION IN HEALTHY INDIVIDUALS
    G H Rueda, N Causada-Calo,R Borojevic,A Nardelli,M Constante, L Loonen,J Wells,H Sokol,E Verdu,P Bercik
    Journal of the Canadian Association of Gastroenterology（2021）
    Abstract Background Tryptophan is an essential amino acid that is transformed by host and gut microbial enzymes into multiple bioactive metabolites that regulate immunity, mood and circadian rhythms. In particular, indoles, produced by gut bacterial metabolism of tryptophan, have...
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    A58 herpes zoster virus infection in pediatric patients with inflammatory bowel disease: single center experience
    A Al-Khuzaei
    Journal of the Canadian Association of Gastroenterology（2021）
    Abstract Background Patients with IBD receive a variety of medications that modulate the immune response. However, many medications render patients more susceptible to opportunistic infections. Varicella zoster virus (VZV) infection, in particular, has been well reported in IBD p...
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    A149 TRP53 LOSS IN KRT15+ INTESTINAL STEM CELLS SEVERELY AFFECTS SECRETORY CELL FATE AND SELF-RENEWAL
    A Dubey,A Gonneaud,V Giroux
    Journal of the Canadian Association of Gastroenterology（2021）
    Abstract Background Intestinal epithelium homeostasis is maintained by two main populations of stem cells: Lgr5+ and reserve stem cells. Under injury, cell plasticity has been observed in progenitor and differentiated cells. We recently reported that Krt15+ cells are present in s...
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    An Unusual Case of Lumen-Apposing Metal Stent–Related Splenic Capsule Hemorrhage
    Dalton R. Budhram,Reza Nasirzadeh,Lawrence Hookey
    Journal of the Canadian Association of Gastroenterology（2020）
    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Rece...
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    A224 COVID-19 INFECTION IN LIVER TRANSPLANT RECIPIENTS: CLINICAL FEATURES, HOSPITALIZATION, AND MORTALITY FROM A CANADIAN MULTICENTRE COHORT
    M K Smith, J Chow, R Huang,M Omar,M Ebadi,P Wong,G Huard,E M Yoshida, D Peretz,M Brahmania,A J Montano-Loza,R Bhanji
    Journal of the Canadian Association of Gastroenterology（2022）
    Abstract Background The COVID-19 pandemic has brought significant challenges to clinicians caring for liver transplant (LT) recipients. Researchers have sought to better understand the risk and clinical outcomes of LT recipients infected with COVID-19 globally, however, there is ...
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    A133 MARGIN THERMAL ABLATION WITH SNARE-TIP SOFT COAGULATION EFFECTIVELY MITIGATES RECURRENCE AFTER ENDOSCOPIC MUCOSAL RESECTION OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS
    S X Jiang,A Zarrin, A Walia,C Galorport,W Xiong,R Enns,E Lam,N Shahidi
    Journal of the Canadian Association of Gastroenterology（2024）
    Abstract Background Recurrence following endoscopic mucosal resection (EMR) historically occurs in approximately 15-20% of large (≥20 mm) non-pedunculated colorectal polyps (LNPCPs). Margin thermal ablation with snare-tip soft coagulation (STSC) of the post-EMR defect is an evide...
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    A181 ENDOSCOPIC BALLOON DILATION IS EFFECTIVE AND SAFE IN THE MANAGEMENT OF NSAID-INDUCED NON-ULCERATIVE GASTRIC OUTLET OBSTRUCTION
    D R Lim,D Farina, W Huang,J Zhu
    Journal of the Canadian Association of Gastroenterology（2020）
    Abstract Background We describe an unusual case of NSAID-induced gastric outlet obstruction (GOO) in the absence of malignancy or ulcers. This was successfully managed conservatively with drug withdrawal and serial endoscopic balloon dilation (EBD). Aims Case Report Methods Case ...
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    A71 POLYP TO ADENOMA CONVERSION FACTOR AS A SURROGATE FOR ADENOMA DETECTION RATE-– FINDINGS FROM THE SOUTHWEST ONTARIO COLONOSCOPY COHORT
    S Alobaid,C Mcdonald,L Guizzetti,B Yan,V Jairath,M Sey
    Journal of the Canadian Association of Gastroenterology（2022）
    Abstract Background The adenoma detection rate (ADR) is one of the main quality indicators of a colonoscopy but requires combining endoscopic and histologic data. However, the polyp detection rate (PDR) requires only endoscopic assessment and has been proposed as a proxy measure ...
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    A72 GASTROPARESIS: CLINICAL CHARACTERISTICS, ETIOLOGIES & RESPONSE TO TREATMENT
    A Letellier, S Rolland
    Journal of the Canadian Association of Gastroenterology（2022）
    Abstract Background Gastroparesis is a gastrointestinal motor disorder characterized by a delay in gastric emptying without evidence of mechanical obstruction. Data pertaining to the demographic and clinical characteristics of gastroparesis in the Canadian population is sparse. A...
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    A149 REAL WORLD OUTCOMES OF NON-MEDICAL SWITCHING OF INFLIXIMAB BIOSIMILAR IN BRITISH COLUMBIA FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD)
    J Reid,G Rosenfeld,C Galorport
    Journal of the Canadian Association of Gastroenterology（2022）
    Abstract Background A mandated non-medical switch to the infliximab biosimilars was launched in British Columbia in 2019. British Columbia was the first province in Canada to mandate the switch from the originator infliximab (RemicadeTM) to one of the 2 approved biosimilars (Infl...
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    A3 CROHN’S DISEASE PROTEOLYTIC MICROBIOTA ENHANCES INFLAMMATION THROUGH PAR2 PATHWAY IN GNOTOBIOTIC MICE
    A Hann,A Santiago Badenas,H J Galipeau,M Constante,J Libertucci,S Rahmani,K Jackson,G Rueda,L Rossi,R Ramachandran,W Ruf,A Caminero,
    Journal of the Canadian Association of Gastroenterology（2023）
    Abstract Background An imbalance in host proteases has been implicated in inflammatory bowel disease (IBD). Recent evidence implicates microbial proteolytic activity (PA) in ulcerative colitis but whether it also plays a role in Crohn’s disease (CD) remains unclear. Purpose We th...
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    A233 OUTCOMES OF CLOSTRIDIOIDES DIFFICILE INFECTION IN SURGICAL PATIENTS: RESULTS FROM NATIONAL INPATIENT SAMPLE 2016-2019
    R Tariq,M W Tahir,S Khanna
    Journal of the Canadian Association of Gastroenterology（2023）
    Abstract Background Clostridioides difficile infection (CDI) is the most common nosocomial infection and is associated with significant morbidity and mortality. Purpose We aimed to identify the burden of CDI in patients undergoing common gastrointestinal (GI) surgical procedures ...
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    A136 THE ROLE OF KERATIN-19 POSITIVE STEM CELLS IN COLONIC REGENERATION POST COLITIS
    E Fazio, R Nattiv,D Castillo-Azofeifa, Y Nusse, J SCHANIN, O Klein,S Asfaha
    Journal of the Canadian Association of Gastroenterology（2018）
    The intestinal and colonic epithelia are rapidly renewed every 3 to 5 days. In the intestine, at least two principal stem cell pools, comprised of rapidly cycling crypt based columnar (CBC) Lgr5+ cells and slower cycling Bmi1-expressing cells located above the crypt base, have be...
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