His research interests have been in hematopoietic stem cell transplantation (HSCT) and hemostasis disorders. Apart from the building the largest HSCT service in the country, his particular research interest was in improving outcomes of HSCT for thalassemia major by evaluating the pharmacokinetics and pharmacogenetics of drugs used for conditioning. He has been instrumental in establishing the Indian Stem Cell Transplant registry 15 years ago and continues to coordinates its activities. Over the last 12 years, he has been responsible for establishing the Centre for Stem Cell Research, Vellore as a translational unit of the Institute of Stem Cell Science and Regenerative Medicine as a collaboration between these two institutes and the Department of Biotechnology, Government of India. At CSCR, the focus is on developing various novel therapies towards for regenerative medicine. The focus of current research is the development of gene therapy for hereditary hematological disorders such as the major haemoglobin disorders – thalassemia and sickle cell disease with the help of several major international collaborations to bring that technology to the country. In parallel, he is also working with several colleagues in different departments of the CMC, Vellore to establish the first large comprehensive control program for the major haemoglobin disorders in India in the collaboration the state government in Odisha.