Dr Cross’ research interests primarily relate to medicine safety and quality use of medicines in older people, particularly those at risk of developing dementia or who are currently living with dementia. She has published 27 articles in scientific journals, including 15 first author articles, and her work is frequently profiled in the professional and public media. Amanda is also a chief investigator on three large Medical Research Future Fund (MRFF) projects, two evaluating novel models of knowledge translation in aged care and one developing medication management resources for people living with dementia. She is currently supervising three PhD students and one Masters student.

Dr Cross continues to practice in a clinical role as a community pharmacist and home medication review pharmacist. Dr Cross is an active member of the Pharmaceutical Society of Australia and was the Victorian Branch Vice President for four years (2017-2021). In 2019 Dr Cross won the award for the Pharmaceutical Society of Australia Victorian Early Career Pharmacist of the Year.