The lab has developed potent approaches for elucidating proximal, distal, and transient protein–protein interactions in cellular milieus, and for determining distance restraints between amino-acid residues within large protein assemblies by chemical cross-linking and mass spectrometry. The long-term goal of this research is to develop a molecular microscope for defining cellular systems with scales spanning all the way from the dimensions of a cell to the atomic resolution of molecules.
The lab has also developed mass spectrometric approaches for defining repertoires of high-affinity nanobodies that develop within llamas against any given antigen, and is investigating their utility in a host of applications including immunotherapy against cancers and the SARS-CoV-2 coronavirus.