His research program focuses on development of unique optical tools and techniques for advanced surgery and radiation therapy guidance, photodynamic therapy, molecular imaging, and theranostics. He has raised $42 Million in NIH funding, translated dozens of imaging systems into human trials, and published >475 scientific peer-reviewed articles. He is Editor in Chief of the Journal of Biomedical Optics, and elected Fellow of AIMBE, Optica, SPIE, AAPM & the National Academy of Inventors.