The fields of study she is best known for: Bacteria Ecology Gene Cheryl R. Kuske mostly deals with Ecology, Soil microbiology, Phylogenetics, Genetics and 16S ribosomal RNA. The study incorporates disciplines such as Terminal restriction fragment length polymorphism and Metagenomics in addition to Ecology. Her Soil microbiology research is multidisciplinary, relying on both Biodiversity, Botany, Nostoc, Rhizosphere and Acidobacteria. Her work deals with themes such as Restriction fragment, Ribosomal RNA, Proteobacteria and Sequence analysis, which intersect with Phylogenetics. Her work on Earth Microbiome Project as part of general Ribosomal RNA study is frequently linked to Database, Human health, Open source and Nucleic acid chemistry, therefore connecting diverse disciplines of science. Many of her research projects under Genetics are closely connected to Mechanism with Mechanism, tying the diverse disciplines of science together.