Dr. Hendrix's primary research focus is chemoprevention of HIV infection. This involves oral, topical, and injectable HIV microbicide development. He conducts small, intensive sampling studies of PK and PD of drugs for HIV prevention with a focus on developing methods to better understand HIV and drug distribution in the male genital tract, female genital tract and lower gastrointestinal tract. He also supports numerous HIV pre-exposure prophylaxis development studies from phase I to phase III, largely as leader of the Pharmacology Core Laboratory of both the Microbicide Trial Network and HIV PRevnetion Trials Network.