The focus of our laboratory is utilizing adenovirus for molecular medicine applications. In this regard, the unique molecular promiscuity of adenovirus allows directed engineering to modify key factors of the virus life cycle and molecular structure. This capacity for directed engineering facilitates the application of adenovirus-based interventions which embody vaccinology, gene therapy, and virotherapy. Our technical focus also projects our work fully within the context of fundamental virology. In parallel, our molecular medicine applications place our work the advanced guard of the emerging field of “vectorology.” These efforts to address key application barriers provides the basis of our extensive network of collaborations that engage our laboratory in the widest range of applied contexts. The strong translational rationale predicated by these collaborations provides the basis of our unique “bench-to-bed” ethos.