David B. Weiner - Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy & Biology

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Structural Engineering of Stabilized, Expanded Epitope Nanoparticle Vaccines for HPV

Michaela Helble,Xizhou Zhu,Pratik S Bhojnagarwala,Kevin Liaw, Yangcheng Gao, Amber Kim, Kelly Bayruns, Madison E McCanna, Joyce Park,Kylie M Konrath, Sam Garfinkle, Taylor Brysgel,David B Weiner,Daniel W Kulp

Frontiers in immunology (2025): 1535261-1535261

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Structure and Sequence Engineering Approaches to Improve in Vivo Expression of Nucleic Acid-Delivered Antibodies

Michaela Helble,Jacqueline Chu, Kaitlyn Flowers, Abigail R. Trachtman, Alana Huynh, Amber Kim, Nicholas Shupin, Casey E. Hojecki,Ebony N. Gary, Shahlo Solieva,Elizabeth M. Parzych,David B. Weiner,Daniel W. Kulp,Ami Patel

MOLECULAR THERAPYno. 1 (2025): 152-167

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Safety and Immunogenicity of an Optimized Self-Replicating RNA Platform for Low Dose or Single Dose Vaccine Applications: a Randomized, Open Label Phase I Study in Healthy Volunteers

Christian J. Maine, Shigeki J. Miyake-Stoner, Darina S. Spasova, Gaelle Picarda, Annie C. Chou, Emily D. Brand, Melanie D. Olesiuk, Christine C. Domingo, Hunter J. Little, Thomas T. Goodman, Jacqueline L. Posy, Jasmin Gonzalez, Terrina L. Bayone,Jessica Sparks,Ebony N. Gary, Zhi Xiang,Nicholas J. Tursi, Casey E. Hojecki,Hildegund C. J. Ertl,David B. Weiner, Irafasha C. Casmil,Anna K. Blakney,Brandon Essink, Guillermo Somodevilla, Nathaniel S. Wang, Andrew J. Geall, Zelanna Goldberg,Parinaz Aliahmad

NATURE COMMUNICATIONSno. 1 (2025)

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DNA Immunotherapy for Recurrent Respiratory Papillomatosis (RRP): Phase 1/2 Study Assessing Efficacy, Safety, and Immunogenicity of INO-3107

Matthew P Morrow, Elisabeth Gillespie,Albert Sylvester,Milan R Amin,Peter C Belafsky, Simon R Best,Aaron D Friedman,Adam M Klein, David G Lott, Ted Mau,Randal C Paniello, Seth M Pransky, Nabil F Saba, Grace S Tan, Sadie Wisotsky, Sarah A Marcus, Emma L Reuschel, Katherine S Reed,David B Weiner, Michael Dallas, Jeffrey M Skolnik

Nature Communicationsno. 1 (2025): 1-16

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Deep Mining of the Human Antibody Repertoire Identifies Frequent and Immunogenetically Diverse CDRH3 Topologies Targetable by Vaccination