Derek M. McKay

基本信息

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职业迁徙

个人简介

I have authored ~150 peer-reviewed publications, given 150 invited presentations, and have been fortunate to receive research awards from the American Gastroenterological Association, American Society for Parasitology, Canadian Association of Gastroenterology (CAG), Canadian Society for Zoologists, and Crohn’s Colitis Canada (CCC). I have served as President of the Canadian Association of Gastroenterology (2014-2016) and as a Councilor for the Canadian Society for Zoologists.

I aim to create a dynamic, multi-disciplinary environment conducting leading edge research on the regulation of intestinal physiology and immunity in health and disease, specifically: (a) the role of the microbiota, immune mediators and mitochondria in the control of epithelial barrier function; and, (b) the use of a helminth-rodent model paradigm to dissect pathways of immunomodulation.

研究兴趣

论文共 417 篇作者统计合作学者相似作者

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A245 CROHN’S DISEASE-ASSOCIATED BACTERIAL PATHOBIONT EVOKED EPITHELIAL MITOCHONDRIAL DAMAGE DRIVES TYPE I INTERFERON EXPRESSION

Alladi Mohan, A Wang,Derek M. McKay,Timothy E. Shutt

Journal of the Canadian Association of Gastroenterologyno. Supplement_1 (2024): 197-198

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A240 THE PROTECTIVE EFFECT OF HYMENOLEPIS DIMINUTA INFECTION IN EXPERIMENTAL COLITIS CAN BE INDEPENDENT OF IL-4RΑ SIGNALING

Leandro Rocha, S Li,Sruthi Rajeev, A Wang,Derek M. McKay

Journal of the Canadian Association of Gastroenterologyno. Supplement_1 (2024): 193-194

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A66 EFFECTS OF HYMENOLEPIS DIMINUTA EXTRACELLULAR VESICLES ON MOUSE MACROPHAGES AND THEIR MITOCHONDRIA

Paige Volk,Thibault Allain, Nadia Khan, A Wang,André G. Buret,Derek M. McKay

Journal of the Canadian Association of Gastroenterologyno. Supplement_1 (2024): 44-45

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Enteric Tuft Cells Coordinate Timely Expulsion of the Tapeworm Hymenolepis Diminuta from the Murine Host by Coordinating Local but Not Systemic Immunity

Sruthi Rajeev, ShuHua Li,Aralia Leon-Coria,Arthur Wang,Lucas Kraemer, Susan Joanne Wang, Annaliese Boim,Kyle Flannigan,Adam Shute,Cristiane H. Baggio,Blanca E. Callejas,Wallace K. MacNaughton,

PLOS PATHOGENSno. 7 (2024)

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A263 IRONING OUT THE DETAILS: CROHN’S DISEASE PATIENT DERIVED MACROPHAGES ARE MORE SUSCEPTIBLE TO FERROPTOSIS

J A Sousa,B E Callejas Pina, Y Munazza, A Wang,M Raman,Derek M. McKay

Journal of the Canadian Association of Gastroenterologyno. Supplement_1 (2024): 211-212

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GPx1 Deficiency Confers Increased Susceptibility to Ferroptosis in Macrophages from Individuals with Active Crohn’s Disease

Derek McKay, James Sousa, Blanca Callejas,Arthur Wang, Eve Higgins, Aydin Herik,Munazza Yousuf,Pina Colarusso,Maitreyi Raman

crossref（2024）

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Calcitonin Gene-Related Peptide Promotes Epithelial Reparative and Anti-Colitic Functions of IL-4 Educated Human Macrophages

Blanca E Callejas, James A Sousa,Kyle L Flannigan,Arthur Wang, Eve Higgins, Aydin Ivan Herik, Shuhua Li, Sruthi Rajeev, Ryan Rosentreter,Remo Panaccione,Derek M McKay

American journal of physiology Gastrointestinal and liver physiology (2024)

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Neuroimmunophysiology of the Gastrointestinal Tract

Derek M McKay,Manon Defaye,Sruthi Rajeev,Wallace K MacNaughton,Yasmin Nasser,Keith A Sharkey

American journal of physiology Gastrointestinal and liver physiology/American journal of physiology Gastrointestinal and liver physiologyno. 6 (2024): G712-G725

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A163 INFECTION WITH HYMENOLEPIS DIMINUTA ELICITS A TH2 IMMUNITY AND ALLEVIATES DNBS-COLITIS IN A MOUSE MODEL WITH MINIMAL INTESTINAL MICROBIOTA

S Li,A Wang,D M McKay

Journal of the Canadian Association of Gastroenterologyno. Supplement_1 (2023): 10-10

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A4 PREDNISOLONE, A GLUCOCORTICOID WIDELY USED FOR TREATMENT OF IBD, ENHANCES A HUMAN INTERLEUKIN-4-ACTIVATED MACROPHAGE PHENOTYPE