Flora Sam

Dr. Sam is an advanced heart failure cardiologist and physician-scientist. She is a PI and an NIH funded, independent investigator whose focus is on mechanisms of myocardial remodeling in cardiomyopathy, hypertrophy and heart failure. In addition to cardiac myocyte biology, she also utilizes both human and animal models in her research. She is a recognized expert in heart failure with preserved ejection fraction (HFpEF), previously known as diastolic heart failure. The Sam lab is focused on three major areas of investigation: 1) Pro-inflammatory and pro-fibrotic mechanisms that mediate cardiac remodeling in heart failure and hypertension. 2) Investigating the relationship between matrix markers and heart failure in humans with cardiac amyloid and 3) Investigating cross talk between adipocyte-derived factors, myokines and cardiokines in heart failure.