I am interested in investigating the causes of psychiatric disorder, particularly depressive illness and psychosis. Causal factors that are potentially preventable could be especially useful but clues to aetiology also can improve our understanding of illness and help to devise treatments. I also carry out randomised controlled trials to evaluate treatments for depression in primary care. I aim to carry out research that has practical implications in improving clinical care of people with psychiatric disorder. I want to identify those advances in our neuroscientific understanding that could lead to practicable benefits for patients.