Professor Iso's international activities include the position of a WHO scientific adviser for noncommunicable diseases. His research field has been epidemiology and prevention of lifestyle-related disease (hypertension, dyslipidemia, diabetes, stroke and ischemic heart disease as well as dementia). Research and educational projects he committed as a principal investigator for large and long-term cohort studies and trials such as Circulatory Risk in Communities Study (CIRCS), Japan Environment & Children's Study (JECS) and Japan Trial in High-risk Individuals to Accelerate their Referral to Physicians: A Nurse-led, Community-based Prevention Program of Lifestyle-related Disease (J-HARP). As a coprincipal investigator, he participated in the Japan Public Health Center-based Prospective Study (JPHC Study), and Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC). He directs Osaka University projects for medical data science (2019-2024) and integrated research on prevention, treatment and care for dementia (2019-2021).