Research interests Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases. Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy. Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort. Study of difficult-to-treat/severe asthma in the Wessex AsThma CoHort of Difficult Asthma (WATCH), a pragmatic real-life longitudinal study of difficult asthma in the clinic.