Dr. Wakelee is a clinical investigator with a focus in lung cancer and other thoracic malignancies. Along with her other colleagues in thoracic medical oncology at Stanford she is focused on clinical trials with agents that are specifically targeted to known mutations in lung cancer such as EGFR, ALK and other "driver" mutations with a particular focus on resistance mechanisms. Earlier work on anti-angiogenesis agents continues as well. The treatment of NSCLC revolves increasingly around the use of immune modulatory agents, particularly PD-(L)1 checkpoint inhibitors and the majority of current trials utilize these drugs including bringing them to patients with earlier stages of disease with a hope to improve cure rates.