Jared Mackenzie - Africa Hlth Res Inst

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个人简介

Currently studying potential compounds for the treatment of Mycobacterium tuberculosis. Compounds of interest include those that target the electron transport chain, as well as various metabolic pathways.

研究兴趣

论文共 15 篇作者统计合作学者相似作者

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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium Tuberculosis Clinical Isolates

Saranathan Rajagopalan,Amy K. Rourke,Emmanuel Asare,Donna J. Kohlerschmidt, Lahari Das, Senamile L. Ngema,Claire Mulholland,Catherine Vilcheze, Vaishnavi Mahalingam,Sashen Moodley,Barry Truebody,Jared Mackenzie,Adrie J. C. Steyn,Rubeshan Perumal,Michael Berney,Michelle H. Larsen,Max R. O'Donnell,Vincent E. Escuyer,William R. Jacobs

JOURNAL OF INFECTIOUS DISEASES (2024)

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Identification of Chemical Scaffolds That Inhibit the Mycobacterium Tuberculosis Respiratory Complex Succinate Dehydrogenase

ACS INFECTIOUS DISEASESno. 10 (2024): 3496-3515

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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium Tuberculosis Clinical Isolates

Saranathan Rajagopalan,Amy K Rourke,Emmanuel Asare,Donna J Kohlerschmidt, Lahari Das, Senamile L Ngema,Claire V Mulholland,Catherine Vilchèze, Vaishnavi Mahalingam,Sashen Moodley,Barry Truebody,Jared Mackenzie,Adrie J C Steyn,Rubeshan Perumal,Michael Berney,Michelle H Larsen,Max R O’Donnell,Vincent E Escuyer,William R Jacobs

The Journal of Infectious Diseases (2024)

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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium Tuberculosis Clinical Isolates

The Journal of infectious diseases (2024)

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Mycobacterium Tuberculosis Senses Host Interferon-γ Via the Membrane Protein MmpL10

Mohamed Ahmed,Jared Mackenzie,Liku Tezera,Robert Krause,Barry Truebody,Diana Garay-Baquero,Andres Vallejo,Katya Govender,John Adamson,Hayden Fisher,Jonathan W. Essex,Salah Mansour,Paul Elkington,Adrie J. C. Steyn,Alasdair Leslie

Communications Biology（2022）

引用6浏览0WOSNATURE引用

Host Immunity Increases Mycobacterium Tuberculosis Reliance on Cytochrome Bd Oxidase

Yi Cai, Eleni Jaecklein,Jared Mackenzie,Kadamba Papavinasasundaram,Andrew J. Olive,Xinchun Chen,Adrie J. C. Steyn,Christopher M. Sassetti

PLoS Pathogens（2021）

引用8浏览0WOS引用

Mycobacterium Tuberculosis H2S Functions As a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility

Tafara T. R. Kunota,Md Aejazur Rahman,Barry E. Truebody,Jared S. Mackenzie,Vikram Saini,Dirk A. Lamprecht,John H. Adamson,Ritesh R. Sevalkar,Jack R. Lancaster,Michael Berney,Joel N. Glasgow,Adrie J. C. Steyn

Antioxidants（2021）

引用9浏览0WOS引用

Hydrogen Sulfide Stimulates Mycobacterium Tuberculosis Respiration, Growth and Pathogenesis

Vikram Saini,Krishna C. Chinta,Vineel P. Reddy,Joel N. Glasgow,Asaf Stein,Dirk A. Lamprecht,Md. Aejazur Rahman,Jared S. Mackenzie,Barry E. Truebody,John H. Adamson,Tafara T. R. Kunota,Shannon M. Bailey,Douglas R. Moellering,Jack R. Lancaster Jr.,Adrie J. C. Steyn

Nature Communications（2020）

引用67浏览0WOSNATURE引用

Bedaquiline Reprograms Central Metabolism to Reveal Glycolytic Vulnerability in Mycobacterium Tuberculosis

Jared S. Mackenzie,Dirk A. Lamprecht, Rukaya Asmal,John H. Adamson,Khushboo Borah,Dany J. V. Beste,Bei Shi Lee,Kevin Pethe,Simon Rousseau,Inna Krieger,James C. Sacchettini,Joel N. Glasgow,Adrie J. C. Steyn

Nature Communicationsno. 1 (2020)

引用28浏览0WOSNATURE引用

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