Research Overview
We have extensively explored new models of computational systems biology and computer-aided drug design to study fundamental theories of molecular interactions (e.g., Molecular Interaction Family) in cells. Our goal is to study drug-protein-pathway-cellular processes-disease relationships, and to establish the links from basic research to translational medicine. To achieve these goals, our team has been committed to integrate artificial intelligence, big data, physico-chemical concepts, and biology for exploring relationships among "molecular interactions", "cell behavior" and "drug discovery principles". To validate our models, we have rigorously collaborated with biological/clinical teams and their bioassay/clinical results support and demonstrate that our models are able to address the challenges and achieve our goals. We have continuously collaborated with researchers from various universities and institutes like NHRI, Academic Sinica, research hospitals (e.g., NTUH, TMU, and KMU) and international institutes (e.g., Kyoto University and Harvard University) for resolving unmet clinical needs and important biological issues.