Joseph Trapani

Professor

Harry Perkins Institute of Medical Research;Cancer Cell Death Laboratory Peter Maccallum Cancer Centre;Victorian Comprehensive Cancer Centre;Department of Microbiology and Immunology, University of Melbourne

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基本信息

Career Trajectory

Bio

Joe’s research interests include the immunopathology of viral and auto-immune diseases, apoptosis induction by cytotoxic lymphocytes and cancer immunotherapy. He has authored > 350 research papers, reviews and book chapters (>30K cites, H-index 91). Joe Trapani was a member of the Executive (Board) of the Cancer Council Victoria (2007-2020) and Chaired its Medical and Scientific Committee (2013-2020). He now participates in many other peer-review bodies for State and Federal governments, and in academia and industry, nationally and internationally.

Research Interests

Papers共 483 篇Author StatisticsCo-AuthorSimilar Experts

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Acidic Ph Can Attenuate Immune Killing Through Inactivation of Perforin

Adrian W. Hodel, Jesse A. Rudd-Schmidt,Tahereh Noori, Christopher J. Lupton, Veronica C. T. Cheuk,Joseph A. Trapani,Bart W. Hoogenboom,Ilia Voskoboinik

EMBO REPORTS (2025)

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Abstract LT02: Regulation of Exhausted CD8+ T Cell Differentiation by IKZF Transcription Factors

Sinead M. Reading,Isabelle Munoz,Maria N. de Menezes,Nicole Y. L. Saw,Krutika Ambani,Antonio Ahn,Simone Nussing,Sara Roth,Shienny Sampurno,Kelly M. Ramsbottom,Joseph A. Trapani,Kim L. Good-Jacobson,Ricky W. Johnstone,Shom Goel,Paul A. Beavis,Ian A. Parish

Cancer Research（2024）

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CRISPR-Cas13b-mediated Suppression of HBV Replication and Protein Expression

Laura C. McCoullough,Mohamed Fareh,Wenxin Hu,Vitina Sozzi, Christina Makhlouf, Yianni Droungas,Chee Leng Lee, Mina Takawy,Stewart A. Fabb,Thomas J. Payne,Colin W. Pouton,Hans J. Netter,Sharon R. Lewin,Damian FJ. Purcell,Jacinta A. Holmes,Joseph A. Trapani,Margaret Littlejohn,Peter A. Revill

JOURNAL OF HEPATOLOGYno. 5 (2024)

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Single-base Tiled Screen Unveils Design Principles of PspCas13b for Potent and Off-Target-free RNA Silencing

Wenxin Hu,Amit Kumar,Syed Faraz Ahmed,Shijiao Qi, David K. G. Ma, Honglin Chen, Gurjeet J. Singh,Joshua M. L. Casan,Michelle Haber,Ilia Voskoboinik,Matthew R. McKay,Joseph A. Trapani,Paul G. Ekert,Mohamed Fareh

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2024）

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SAT-377 CRISPR-Cas13b-mediated Suppression of Hepatitis B Surface Antigen-Pre-clinical Investigations of a New Therapeutic Approach

Laura McCoullough,Mohamed Fareh, Wenxin Hu,Vitina Sozzi, Christina Makhlouf, Yianni Droungas,Chee Leng Lee,Hans Netter, Mina Takawy,Sharon Lewin,Damian Purcell,Jacinta Holmes,Joseph Trapani,Margaret Littlejohn,Peter Revill

Journal of Hepatology (2024): S740

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The CD8+ T Cell Tolerance Checkpoint Triggers a Distinct Differentiation State Defined by Protein Translation Defects

Willem Van Der Byl,Simone Nussing,Timothy J. Peters,Antonio Ahn,Hanjie Li,Guy Ledergor,Eyal David,Andrew S. Koh,Mayura V. Wagle, Christian Deo T. Deguit,Maria N. de Menezes, Avraham Travers,Shienny Sampurno,Kelly M. Ramsbottom,Rui Li,Axel Kallies,Paul A. Beavis,Ralf Jungmann,Maartje M. C. Bastings,Gabrielle T. Belz,Shom Goel,Joseph A. Trapani,Gerald R. Crabtree,Howard Y. Chang,Ido Amit,Chris C. Goodnow,Fabio Luciani,Ian A. Parish

Immunityno. 6 (2024): 1324-1344.e8

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Pharmacologic Inhibition of Dipeptidyl Peptidase 1 (cathepsin C) Does Not Block in Vitro Granzyme-Mediated Target Cell Killing by CD8 T or NK Cells

Vivien R. Sutton,Sally V. Watt,Hedieh Akhlaghi,David C. Cipolla,Kuan-Ju Chen,Daniel Lasala,Patrick P. Mcdonald,Paul A. Beavis,Isabelle Munoz,Adrian W. Hodel,Tahereh Noori,Ilia Voskoboinik,Joseph A. Trapani

Frontiers in Pharmacology (2024)

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Tissue-colonizing Disseminated Tumor Cells Secrete Prostaglandin E2 to Promote NK Cell Dysfunction and Evade Anti-Metastatic Immunity

Anna-Marie Pedde,Hyunu Kim,Sainitin Donakonda,Tobias Baumann,Felix Bayerl,Philippa Meiser,Anna Hirschberger,Christine Klement,Simon Grassmann,Rupert Oellinger,Norbert Hueser,Daniel Hartmann,Melanie Laschinger,Joseph A. Trapani,Alfred Zippelius, Tobias Bald,Gabriela M. Wiedemann,Roland Rad,Joseph C. Sun,Bastian Hoechst,Jan P. Boettcher

CELL REPORTSno. 11 (2024)

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Acidic Ph Attenuates Immune Killing Through Inactivation of Perforin

Adrian W Hodel,Jesse A Rudd-Schmidt,Tahereh Noori,Christopher J Lupton, Veronica CT Cheuk,Joseph A Trapani,Bart W Hoogenboom,Ilia Voskoboinik

biorxiv（2024）

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Cancer Cell-Specific PD-L1 Expression is a Predictor of Poor Outcome in Patients with Locally Advanced Oral Cavity Squamous Cell Carcinoma

Minyu Wang, Lei Qin,Kevin Thia,Thu Nguyen,Sean Macdonald, Simone Belobrov,Sevastjan Kranz,David Goode,Joseph A. Trapani,David Wiesenfeld,Paul Joseph Neeson

JOURNAL FOR IMMUNOTHERAPY OF CANCER（2024）

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Author Statistics

#Papers: 484

#Citation: 31178

H-Index: 89

G-Index: 165

Sociability: 7

Diversity: 4

Activity: 94

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