Both his clinical and research activities are focused on the immunobiology of leukemia in the model setting of allogeneic hematopoietic cell transplantation, and in particular on the mechanisms of leukemia immune escape and relapse. His main contributions to science relate to the description of the mechanisms by which leukemia reappears after transplantation, to dissecting the clinical correlates of Natural Killer cell reconstitution upon transplantation, and to the development of new cutting-edge molecular methods to improve the early detection of leukemia recurrence.

My research is focused on elucidating the interplay between immune system and leukemia, especially in the model system of allogeneic Hematopoietic Cell Transplantation. In particular, my group focuses on understanding mechanism by which post-transplantation relapses occur, combining cutting-edge immunogenomic analysis of patient samples with the development of innovative preclinical models. Our long-term aim is to develop personalized therapeutic approaches able to rewire a proficient graft-versus-tumor effect.