I am a Research Fellow and Clinical Haematologist with a specialist interest in Myelodysplastic syndromes and Acute Myeloid Leukaemia (AML). These are oligoclonal myeloid malignancies where genetically distinct clones can result in differences in leukaemia cell function within individual patients. I am investigating how clonal heterogeneity affects the biology of leukaemia stem cells in MDS and AML, in particular response to novel anti-leukaemic therapies. I am integrating genomic and functional approaches, including single cell techniques to elucidate clonal structures, epigenetic and transcriptional heterogeneity. My research and clinical interest converge on the common goal to develop better therapies to MDS and AML patients.