Marcus Schultz has performed over 60 clinical trials, published numerous articles in medical journals and various chapters in scientific books, has received several research awards, and serves as a reviewer and editor of numerous international medical journals.

His main research interests are in the area of lung injury, pneumonia and mechanical ventilation. Marcus Schultz initiated several studies focusing on mechanical ventilation settings during general anaesthesia for surgery. Marcus Schultz initiated national and international projects aiming at implementation of intensive care unit strategies in daily critical care practice in high–income countries as well as in resource–limited ICUs in middle– and low–income countries (Pakistan, India, Bangladesh, Nepal, Sri Lanka, Maldives, Malaysia, Myanmar, Thailand, Vietnam, and Brazil).