Dr. Tremblay’s research focuses on aging and cognition, using both animal and human brain models to explore the significance of microglial remodelling of neuronal circuits and elimination of synapses in the pathogenesis of brain disorders. She has developed state-of-the-art expertise in non-invasive imaging of the brain—combining chronic longitudinal two-photon in vivo imaging and correlative immunocytochemical electron microscopy with 3D reconstruction—to study the physiological roles of immune cells across the lifespan.