基本信息
浏览量:445

个人简介
Physician Scientist | Translational Research Leader | Precision Medicine Innovator
I am a physician scientist and epidemiologist with over 15 years of experience at the forefront of human genetics, translational research, and precision medicine. Accredited in Pharmaceutical Medicine, I combine clinical expertise with a passion for leveraging large-scale data to transform disease understanding and accelerate drug discovery and development.
Key Expertise:
Translational Research: Integrating genomic, proteomic, and metabolomic data to uncover disease mechanisms, evaluate therapeutic targets, and identify biomarkers for diagnosis, prognosis, and treatment response.
Precision Medicine: Developing patient-centered approaches by combining genetics e.g. with polygenic risk scores, pharmacogenetics, and multi-omics to optimize therapies tailored to individual needs.
Causal Inference in Drug Discovery: Applying Mendelian randomization and advanced methodologies to identify and validate therapeutic targets, particularly in cardiovascular and metabolic diseases.
Career Highlights:
Leadership in genetics research at 23andMe, where I explore genetic variants associated with drug response (e.g., semaglutide) to inform personalized medicine and drug development.
Faculty roles at the University of Oxford and the University of Pennsylvania, directing multidisciplinary teams conducting translational research bridging human genetics and disease biology.
Extensive use of omics data—genomics, proteomics, metabolomics—to uncover causal biomarkers, elucidate disease mechanisms, and prioritize therapeutic targets for drug development.
Proven track record of publishing translational discoveries, creating a foundation for innovative therapeutic strategies.
Leadership and Collaboration:
With a collaborative mindset, I build and lead multidisciplinary teams of clinicians, scientists, and data experts. My leadership emphasizes innovation, mentorship, and teamwork to solve complex biomedical challenges.
Relevance to Drug Development:
My work supports early-stage drug development by identifying genetically supported targets, uncovering mechanisms of action, and defining biomarker signatures to de-risk therapeutic strategies.
What Drives Me:
I am passionate about transforming data into actionable insights to improve health outcomes. By bridging science and medicine, I aim to enable precision therapies and drive innovation in drug development
I am a physician scientist and epidemiologist with over 15 years of experience at the forefront of human genetics, translational research, and precision medicine. Accredited in Pharmaceutical Medicine, I combine clinical expertise with a passion for leveraging large-scale data to transform disease understanding and accelerate drug discovery and development.
Key Expertise:
Translational Research: Integrating genomic, proteomic, and metabolomic data to uncover disease mechanisms, evaluate therapeutic targets, and identify biomarkers for diagnosis, prognosis, and treatment response.
Precision Medicine: Developing patient-centered approaches by combining genetics e.g. with polygenic risk scores, pharmacogenetics, and multi-omics to optimize therapies tailored to individual needs.
Causal Inference in Drug Discovery: Applying Mendelian randomization and advanced methodologies to identify and validate therapeutic targets, particularly in cardiovascular and metabolic diseases.
Career Highlights:
Leadership in genetics research at 23andMe, where I explore genetic variants associated with drug response (e.g., semaglutide) to inform personalized medicine and drug development.
Faculty roles at the University of Oxford and the University of Pennsylvania, directing multidisciplinary teams conducting translational research bridging human genetics and disease biology.
Extensive use of omics data—genomics, proteomics, metabolomics—to uncover causal biomarkers, elucidate disease mechanisms, and prioritize therapeutic targets for drug development.
Proven track record of publishing translational discoveries, creating a foundation for innovative therapeutic strategies.
Leadership and Collaboration:
With a collaborative mindset, I build and lead multidisciplinary teams of clinicians, scientists, and data experts. My leadership emphasizes innovation, mentorship, and teamwork to solve complex biomedical challenges.
Relevance to Drug Development:
My work supports early-stage drug development by identifying genetically supported targets, uncovering mechanisms of action, and defining biomarker signatures to de-risk therapeutic strategies.
What Drives Me:
I am passionate about transforming data into actionable insights to improve health outcomes. By bridging science and medicine, I aim to enable precision therapies and drive innovation in drug development
研究兴趣
论文共 654 篇作者统计合作学者相似作者
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引用量
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期刊级别
合作者
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medrxiv(2024)
medrxiv(2024)
Jennifer J Brady, Kira Kalkus, Dominique T Nguyen, Jingran Wen,Zachary L Fuller, Yue Qi, Shaeloren S Deering, Leah Selcer,Suyash S Shringarpure, TheandMe Research Team,Michael V Holmes,Xin Wang
medrxiv(2024)
Yu Cao, Christina Ferren, Jessica Desmond, Kartika Venugopal, Mohit Gupta, Rebecca Levy, Donghui Li,Giulia Schiroli, Chunxi Zeng, Lei Liu,Lorenzo Tozzi, Alberto De Iaco,Ulrike Gerdemann,Francesca Alvarez Calderon,Leslie Kean,Cecilia Cotta-Ramusino,Rahul Palchaudhuri, Jane Wang, Jason Rodriguez,James Rottman, Bill Querbes,Michael Holmes
Regular and Young Investigator Award Abstracts (2024)
Keaton Stagaman, Matthew Kmiecik, Madeleine Wetzel,Stella Aslibekyan,Teresa Filshtein Sonmez,Pierre Fontanillas,Michael Holmes,Seth Walk,Madelyn Houser,Lucy Norcliffe-Kaufmann
openalex(2024)
Journal of bone and mineral research the official journal of the American Society for Bone and Mineral Researchno. 11 (2024): 1539-1552
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作者统计
#Papers: 665
#Citation: 44759
H-Index: 94
G-Index: 204
Sociability: 8
Diversity: 4
Activity: 65
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