Our research focuses on the issues pertaining to the development, progression, treatment and prevention of gynecological tumors by looking at the pathological and morphological aspects that contribute to the disorder and symptoms, plus the organ, tissue and molecular interaction networks in order to come up with the relevant clinical solutions. All benign and malignant gynecological tumors are investigated from various perspectives via collaborations with different departments within the campus. Our collaborative endeavors are summarized as the following. The role of oxidative and electrophilic stress response in the development and progression of cervical cancer (Department of Medical Biochemistry: Professor Yamamoto) . The molecular pathology of estrogen-dependent tumors endometrial cancer, ovarian cancer and breast cancer and conditions such as endometriosis are investigated to elucidate their development and progression mechanisms (Department of Diagnostic Pathology: Professor Sasano). Discovery of novel molecular diagnostics for estrogen-dependent cancers such as endometrial and breast cancers using microarray and fluorescent imaging technologies (Department of Molecular Diagnostics: Professor Hayashi) . Elucidation of the epigenetic molecular mechanisms of mammalian embryological development, differentiation and tumorigenesis and the practical development of application of tissue stem cells in regenerative medicine (Innovation of New Biomedical Engineering Center: Associate Professor Arima) . Research in the molecular pathways of vasculogenesis in gynecological tumors (Department of Tumor Vasculation: Professor Sato) . The elucidation of the physiological significance of the Hrs gene, particularly its role in epithelial-mesenchymal transition (EMT)(Department of Immunology: Professor Sugamura) .