Since 2009, the Fondation Imagine followed the “next” generation sequencer evolution and acquired severall machines more and more powerful. The increasing amount of data generated by these technologies created new challenging issues to store, analyze, integrate and visualize pertinent information. To reach this goal, we have developed a new original pipeline to analyze resequencing projects. Our pipeline, Polypipeline is based on public tools (alignment, variation finding) as well as an original database design PolyDB (storage and minning data) and finally a new graphical interface Polyweb (interpretation and visualization). Our tool is completely generic and is independant from the sequencing technology used.
Our team participates also to various projects, either relating to sequencing like chip/seq, rna/seq… or more broadly to biostatistics like transcriptomic, pathway analysis… We can also help the researcher during the design step of her/his experiment to optimize the odds of positive findings.