My academic training is in Clinical Psychology and psychophysiology. I serve as Chair for the Department of Behavioral Science, and I am the Director of the Tobacco Treatment Program. I have over 30 years' experience conducting basic and clinical research in the area of smoking cessation and nicotine psychopharmacology. My major research interests include studies developing novel behavioral and pharmacological treatments for nicotine dependence, and those that study individual differences associated with treatment outcome. In particular my work in this area has focused on psychological (negative affect, coping self-efficacy), psychophysiological (emotional reactivity), neural (EEG/fMRI) and genetic predictors of treatment outcome (pharmacogenetics). In addition to community based samples my work has also involved populations with psychiatric and medical co-morbidities including depression, pregnancy and cancer. I have authored over 250 articles and book chapters, conducted over 21 NIH- and other-sponsored randomized clinical trials examining behavioral and pharmacological interventions for smoking cessation, and served as a senior co-investigator on over 23 NIH-sponsored trials, and mentored 20 junior scientists. I am presently the PI or site PI on 3 active NIH-funded; 2 active CPRIT funded (Cancer Prevention Institute of Texas).