The research laboratory of the Department of Pulmonary Medicine focuses on fundamental, translational and clinical research concerning the pathology of various respiratory disorders. In this context, the research interests include the differentiation program of lymphoid cells in health and disease, using molecular approaches and animal models. The aims comprise the characterization of signal transduction pathways and lymphoid-specific transcription factors that implement cell fate decisions at specific checkpoints. One the one hand, there is a focus in the lab on the involvement of innate lymphoid cells and the T helper 2 subset in type II immunity, particularly in human allergic asthma and in mice. T cell subsets are also studied in a range of other respiratory disorders, including sarcoidosis and community-acquired pneumonia. On the other hand, there is a strong interest in B cell receptor signaling, particularly Bruton’s tyrosine kinase (BTK), both in B cell differentiation and in autoimmune inflammation in systemic autoimmunity and interstitial lung disease (ILD).