Progress in brain tumors treatment have been lagging other cancers for a variety of reasons. The brain is physiologically surrounded by a special barrier that protect it from toxins and damage, however, often also protects tumor cells from medical treatment. We are investigating innovative strategies to open the blood-brain barrier selectively, temporarily, and reversibly, thus facilitate novel medicines (including immunotherapy) to reach tumor in higher concentrations. When treating brain tumors and developing novel treatments, early evaluation of treatment response it of utmost importance and allows to rapidly adapt treatment strategy as needed. Cutting edge imaging technology paired with specialized expertise are available to accurately evaluate tumor growth and tumor response. Numerous clinical trials led by Dr. Stupp and his colleagues provide access to cutting edge brain tumor treatments and care.