We currently have different research lines. (1) We study the key molecules that play a role in the activated detrimental processes at the BCSFB upon inflammation, focusing on barrier integrity, extracellular vesicles (exosomes), and acute phase response. (2) We study whether the choroid plexus is ‘the missing link’ in the body-to-brain axis, due to its unique position between blood and brain. Hereto, we are investigating whether peripheral inflammatory triggers, e.g. in the gastrointestinal system, affect the CPE and consequently increase the sensitivity for the development of neuroinflammatory diseases. (3) We explore whether the CPE can be used as a delivery route to the brain.