I am an experimental medicine researcher and a clinical diabetes physician. I use multiple methods to investigate clinical problems in diabetes therapies, including hypoglycaemia in insulin therapy, the role of the brain in the control of peripheral metabolism, and the impact of black African ethnicity on the metabolic derangements that lead to type 2 diabetes. I work collaboratively with colleagues in neuroimaging, nutrition, psychology and education and transplantation to improve outcomes particularly for adults with type 1 diabetes. With Sheffield and North Tyneside, and nursing colleagues from King's College Hospital, I led the King's team in the development of the patient education programme DAFNE, still the only such programme in the UK that is NICE-approved. We continue to work on improvements to the original curriculum. With the King's Liver teams, we also developed islet transplantation at King's for adults with type 1 diabetes and treatment-resistant hypoglycaemia. Physiological and neuroimaging studies followed by qualitative work with people with diabetes led us to conclude that cognitive barriers to hypoglycaemia avoidance may contribute to high risk of severe hypoglycaemia during insulin therapy and we are now running a multi-centre RCT of a novel intervention using cognitive approaches for people who struggle to avoid recurrent severe hypoglycaemia in the management of their type 1 diabetes.