Dr. Cosgrove’s research interests include the epidemiology and outcomes of antimicrobial resistance, the development of tools and programs to promote the rational use of antimicrobials, the prevention of hospital-acquired infections, and the epidemiology and management of S. aureus bacteremia. Early in her career, she recognized the critical need to study antimicrobial stewardship strategies and has led a series of outcomes studies over the past 20 years that have defined the practice of antimicrobial stewardship in the United States. Her recent research focuses on strategies for implementation of antimicrobial stewardship activities across all healthcare settings via a large, multi-center project including hospitals, long-term care facilities and ambulatory practices funded by the Agency for Healthcare Research and Quality, and approaches to improve how antibiotics are given via a randomized trial to compare intravenous and oral therapy for Gram negative bacteremia funded by PCORI. She is the PI of the Johns Hopkins Prevention Epicenter, a Centers for Disease Control and Prevention-funded program that integrates antimicrobial stewardship, healthcare epidemiology, human factors engineering, data science, and implementation science to address knowledge gaps and develop strategies to optimize patient safety by preventing transmission of pathogens and improving antibiotic use in diverse healthcare settings and patient populations. She is a past voting member of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria. She is a Past President of the Society for Healthcare Epidemiology’s Board of Directors.