Tim Chiu - Arbutus Biopharma Inc | 人才画像

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Papers共 9 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Structure-Activity Relationships and Discovery of (S)-6-isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydr O-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Dimitar Gotchev,Bruce D. Dorsey,Duyan Nguyen,Ramesh Kakarla,Benjamin Dugan,Shuai Chen,Min Gao,Lauren Bailey,Fei Liu,Troy Harasym,Tim Chiu,Sunny Tang,Amy C. -H. Lee,Andrew G. Cole,Michael J. Sofia

Journal of Medicinal Chemistryno. 2 (2024): 1421-1446

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Structure-Activity Relationships and Discovery of (S)-5-(tert-butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1, 2,5,6-Tetrahydropyrido[2′,1′:2,3]Imidazo[4,5-h]quinoline-3-carbox Ylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer

Dimitar Gotchev, Shuai Chen,Benjamin Dugan,Bruce D. Dorsey, Xu Wang,Muhammad Sheraz,Rose Kowalski,Fei Liu,Sunny Tang,Tim Chiu,Troy Harasym,Ingrid E. Graves,Emily P. Thi, Jeremy D. Mason, Nathan Overholt, Ravi Dugyala,Angela M. Lam,Andrew G. Cole,Michael J. Sofia

JOURNAL OF MEDICINAL CHEMISTRYno. 22 (2024): 20467-20494

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Design, Synthesis, and Structure-Activity Relationship of a Bicyclic HBV Capsid Assembly Modulator Chemotype Leading to the Identification of Clinical Candidate AB-506

Andrew G. Cole,Steven G. Kultgen,Nagraj Mani,Jorge G. Quintero,Kristi Yi Fan,Andrzej Ardzinski,Kim Stever,Bruce D. Dorsey,Janet R. Phelps,Amy C. H. Lee,Emily P. Thi,Tim Chiu,Sunny Tang,Peter S. Horanyi,Stephen J. Mayclin,Troy O. Harasym,Michael J. Sofia

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2023)

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The Identification of Highly Efficacious Functionalised Tetrahydrocyclopenta[c]pyrroles As Inhibitors of HBV Viral Replication Through Modulation of HBV Capsid Assembly

Andrew G. Cole,Steven G. Kultgen,Nagraj Mani,Andrzej Ardzinski,Kristi Yi Fan,Emily P. Thi,Bruce D. Dorsey,Kim Stever,Tim Chiu,Sunny Tang,Owen Daly,Janet R. Phelps,Troy Harasym,Andrea Olland,Robert K. Suto,Michael J. Sofia

RSC Medicinal Chemistryno. 3 (2022): 343-349

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