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Synthesis and Evaluation of Aniline Headgroups for Alkynyl Thienopyrimidine Dual EGFR/ErbB-2 Kinase Inhibitors

Alex G. Waterson,Kimberly G. Petrov,Keith R. Hornberger,Robert D. Hubbard,Douglas M. Sammond,Stephon C. Smith,Hamilton D. Dickson,Thomas R. Caferro,Kevin W. Hinkle,Kirk L. Stevens,Scott H. Dickerson,David W. Rusnak,Glenn M. Spehar,Edgar R. Wood,Robert J. Griffin,David E. Uehling

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 48|Views53

Key words

Kinase inhibitor,EGFR,ErbB-2,Medicinal chemistry

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