Convenient synthesis of sorafenib and its derivatives

Lijuan Zhang,Wenpin Xia,Bo Wang,Yu Luo,Wei Lü

SYNTHETIC COMMUNICATIONS（2011）

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摘要

This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation.

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关键词

Aminolysis,phenyl carbamate,sorafenib,unsymmetrical urea

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