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Sirna-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Rob S. Burke,Inthirai Somasuntharam,Paul Rearden,Duncan Brown,Sujal V. Deshmukh,Martha A. DiPietro,Jillian DiMuzio,Roy Eisenhandler,Scott E. Fauty,Christopher Gibson,Marian E. Gindy, Kelly A. Hamilton,Ian Knemeyer,Kenneth A. Koeplinger, Hae Won Kwon,Traci Q. Lifsted,Karsten Menzel,Mihir Patel,Nicole Pudvah,Deanne Jackson Rudd,Jessica Seitzer,Walter R. Strapps,Thomayant Prueksaritanont,Charles D. Thompson,Jerome H. Hochman,Brian A. Carr

Pharmaceutical Research（2014）

Cited 4|Views35
Key words
P450 oxidoreductase,siRNA,drug metabolism,pharmacokinetics
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