Development of Potent Macrocyclic Inhibitors of Genotype 3a HCV NS3/4A Protease.
Michael T. Rudd,John A. McCauley,Joseph J. Romano,John W. Butcher,Kimberly Bush,Charles J. McIntyre,Kevin T. Nguyen,Kevin F. Gilbert,Terry A. Lyle,M. Katharine Holloway,Bang-Lin Wan,Joseph P. Vacca,Vincenzo Summa,Steven Harper,Michael Rowley,Steven S. Carroll,Christine Burlein,Jillian M. DiMuzio,Adam Gates,Donald J. Graham,Qian Huang,Steven W. Ludmerer,Stephanie McClain,Carolyn McHale,Mark Stahlhut,Christine Fandozzi,Anne Taylor,Nicole Trainor,David B. Olsen,Nigel J. Liverton Bioorganic & Medicinal Chemistry Letters(2012)
Key words
Hepatitis C,NS3/4A protease,Macrocycle,Alkoxyquinoline,P2-P4 linker
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