A Meta-Analysis Identifies New Loci Associated with Body Mass Index in Individuals of African Ancestry

Keri L Monda,Gary K Chen,Kira C Taylor,Cameron Palmer,Todd L Edwards,Leslie A Lange,Maggie C Y Ng,Adebowale A Adeyemo,Matthew A Allison,Lawrence F Bielak,Guanjie Chen,Mariaelisa Graff,Marguerite R Irvin,Suhn K Rhie,Guo Li,Yongmei Liu,Youfang Liu,Yingchang Lu,Michael A Nalls,Yan V Sun,Mary K Wojczynski,Lisa R Yanek,Melinda C Aldrich,Adeyinka Ademola,Christopher I Amos,Elisa V Bandera,Cathryn H Bock,Angela Britton,Ulrich Broeckel,Quiyin Cai,Neil E Caporaso,Chris S Carlson,John Carpten,Graham Casey,Wei-Min Chen,Fang Chen,Yii-Der I Chen,Charleston W K Chiang,Gerhard A Coetzee,Ellen Demerath,Sandra L Deming-Halverson,Ryan W Driver,Patricia Dubbert,Mary F Feitosa,Ye Feng,Barry I Freedman,Elizabeth M Gillanders,Omri Gottesman,Xiuqing Guo,Talin Haritunians,Tamara Harris,Curtis C Harris,Anselm J M Hennis,Dena G Hernandez,Lorna H McNeill,Timothy D Howard,Barbara V Howard,Virginia J Howard,Karen C Johnson,Sun J Kang,Brendan J Keating,Suzanne Kolb,Lewis H Kuller,Abdullah Kutlar,Carl D Langefeld,Guillaume Lettre,Kurt Lohman,Vaneet Lotay,Helen Lyon,JoAnn E Manson,William Maixner,Yan A Meng,Kristine R Monroe,Imran Morhason-Bello,Adam B Murphy,Josyf C Mychaleckyj,Rajiv Nadukuru,Katherine L Nathanson,Uma Nayak,Amidou N'Diaye,Barbara Nemesure,Suh-Yuh Wu,M Cristina Leske,Christine Neslund-Dudas,Marian Neuhouser,Sarah Nyante,Heather Ochs-Balcom,Adesola Ogunniyi,Temidayo O Ogundiran,Oladosu Ojengbede,Olufunmilayo I Olopade,Julie R Palmer,Edward A Ruiz-Narvaez,Nicholette D Palmer,Michael F Press,Evandine Rampersaud,Laura J Rasmussen-Torvik,Jorge L Rodriguez-Gil,Babatunde Salako,Eric E Schadt,Ann G Schwartz,Daniel A Shriner,David Siscovick,Shad B Smith,Sylvia Wassertheil-Smoller,Elizabeth K Speliotes,Margaret R Spitz,Lara Sucheston,Herman Taylor,Bamidele O Tayo,Margaret A Tucker,David J Van Den Berg,Digna R Velez Edwards, Zhaoming Wang,John K Wiencke,Thomas W Winkler,John S Witte,Margaret Wrensch,Xifeng Wu,James J Yang,Albert M Levin,Taylor R Young,Neil A Zakai,Mary Cushman,Krista A Zanetti,Jing Hua Zhao,Wei Zhao,Yonglan Zheng,Jie Zhou,Regina G Ziegler,Joseph M Zmuda,Jyotika K Fernandes,Gary S Gilkeson,Diane L Kamen,Kelly J Hunt,Ida J Spruill,Christine B Ambrosone,Stefan Ambs,Donna K Arnett,Larry Atwood,Diane M Becker,Sonja I Berndt,Leslie Bernstein,William J Blot,Ingrid B Borecki,Erwin P Bottinger,Donald W Bowden,Gregory Burke,Stephen J Chanock,Richard S Cooper,Jingzhong Ding,David Duggan,Michele K Evans,Caroline Fox,W Timothy Garvey,Jonathan P Bradfield,Hakon Hakonarson,Struan F A Grant,Ann Hsing,Lisa Chu,Jennifer J Hu,Dezheng Huo,Sue A Ingles,Esther M John,Joanne M Jordan,Edmond K Kabagambe,Sharon L R Kardia,Rick A Kittles,Phyllis J Goodman,Eric A Klein,Laurence N Kolonel,Loic Le Marchand,Simin Liu,Barbara McKnight,Robert C Millikan,Thomas H Mosley,Badri Padhukasahasram,L Keoki Williams,Sanjay R Patel,Ulrike Peters,Curtis A Pettaway,Patricia A Peyser,Bruce M Psaty,Susan Redline,Charles N Rotimi,Benjamin A Rybicki,Michèle M Sale,Pamela J Schreiner,Lisa B Signorello,Andrew B Singleton,Janet L Stanford,Sara S Strom,Michael J Thun,Mara Vitolins,Wei Zheng,Jason H Moore,Scott M Williams,Shamika Ketkar,Xiaofeng Zhu,Alan B Zonderman,Charles Kooperberg,George J Papanicolaou,Brian E Henderson,Alex P Reiner,Joel N Hirschhorn,Ruth J F Loos,Kari E North,Christopher A Haiman

Nature Genetics（2013）

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摘要

Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A .

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Genome-wide Association Studies

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