Structure Based Design of Novel 6,5 Heterobicyclic Mitogen-Activated Protein Kinase Kinase (MEK) Inhibitors Leading to the Discovery of Imidazo[1,5-A] Pyrazine G-479
Bioorganic & Medicinal Chemistry Letters（2014）
Key words
Mitogen-activated protein kinase kinase inhibitors,MEK inhibitors,RAS signaling pathway,Imidazo[1,5-a] pyrazine,Imidazo[1,5-a] pyridine,Structure based drug design (SBDD),Oncology
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