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Discovery of (R)-6-(1-(8-fluoro-6-(1-methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6h)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust in Vivo Antitumor Activity

Alessandro A. Boezio,Katrina W. Copeland,Karen Rex,Brian K. Albrecht,David Bauer,Steven F. Bellon,Christiane Boezio,Martin A. Broome,Deborah Choquette,Angela Coxon,Isabelle Dussault,Satoko Hirai,Richard Lewis,Min-Hwa Jasmine Lin,Julia Lohman,Jingzhou Liu,Emily A. Peterson,Michele Potashman,Roman Shimanovich,Yohannes Teffera,Douglas A. Whittington, Karma Vaida,Jean-Christophe Harmange

Journal of Medicinal Chemistry（2016）

Cited 33|Views48
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