Metabolic Gene Expression Profile in Circulating Mononuclear Cells Reflects Obesity-Associated Metabolic Inflexibility

Sonia Baig,Ehsan Parvaresh Rizi,Muhammad Shabeer,Vanna Chhay,Shao Feng Mok,Tze Ping Loh,Faidon Magkos,Antonio Vidal-Puig,E. Shyong Tai,Chin Meng Khoo,Sue-Anne Toh

Nutrition and Metabolism（2016）

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摘要

Obesity is associated with an impaired ability to switch from fatty acid to glucose oxidation during the fasted to fed transition, particularly in skeletal muscle. However, whether such metabolic inflexibility is reflected at the gene transcription level in circulatory mononuclear cells (MNC) is not known.

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关键词

Mononuclear cells,Metabolic flexibility,Gene expression,Macronutrients,Obesity

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