Discovery and Process Development of a Novel TACE Inhibitor for the Topical Treatment of Psoriasis.
Jean-Guy Boiteau,Gilles Ouvry,Jean-Marie Arlabosse, Stephanie Astri,Audrey Beillard,Yushma Bhurruth-Alcor,Laetitia Bonnary,Claire Bouix-Peter,Karine Bouquet,Marilyne Bourotte,Isabelle Cardinaud,Catherine Comino,Benoit Deprez,Denis Duvert, Angelique Feret,Feriel Hacini-Rachinel,Craig S. Harris,Anne-Pascale Luzy,Arnaud Mathieu,Corinne Millois,Nicolas Orsini,Jonathan Pascau, Artur Pinto,David Piwnica, Gaelle Polge,Arnaud Reitz,Kevin Reverse,Nicolas Rodeville,Patricia Rossio, Delphine Spiesse,Samuel Tabet,Nathalie Taquet,Loic Tomas,Emmanuel Vial,Laurent F. Hennequin Bioorganic & Medicinal Chemistry（2018）
Key words
TACE inhibitor,Psoriasis,Solubility,Polymorph,Aminonitrile synthesis
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