Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model. Joseph E. Pero , Jay M. Matthews , David J. Behm , Edward J. Brnardic , Carl Brooks , Brian W. Budzik , Melissa H. Costell , Carla A. Donatelli , Stephen H. Eisennagel , Karl Erhard , Michael C. Fischer , Dennis A. Holt , Larry J. Jolivette , Huijie Li , Peng Li , John J. McAtee , Brent W. McCleland , Israil Pendrak , Lorraine M. Posobiec , Katrina L. K. Rivera , Ralph A. Rivero , Theresa J. Roethke , Matthew R. Sender , Arthur Shu , Lamont R. Terrell , Kalindi Vaidya , Xiaoping Xu , Brian G. Lawhorn Journal of Medicinal Chemistry（2018）
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