4,8-Disubstituted Pyrimido[5,4-D]pyrimidines As Novel Apoptotic Independent Anticancer Agents: Synthesis and in Vitro Activity Against HCT116 Human Colon Cancer Cells

The author acknowledges the University of Minho, FCT: projects noF-COMP-01-0124- FEDER-022716 (ref. FCT PEst-/QUI/UI0686/2011) FEDER-COMPETE, National NMR Network (Bruker 400 Avance III), research grant Pest-C/BIA/UI4050/2011, co-funded by the program COMPETE from QREN with co-participation from the European Community fund FEDER and PhD grant awarded to A. Rocha SFRH/BD/85937/2012 for financial support.