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Discovery of a Benzothiophene-Flavonol Halting Miltefosine and Antimonial Drug Resistance in Leishmania Parasites Through the Application of Medicinal Chemistry, Screening and Genomics

Chiara Borsari,Maria Dolores Jimenez-Anton,Julia Eick,Eugenia Bifeld,Juan Jose Torrado,Ana Isabel Olias-Molero,Maria Jesus Corral,Nuno Santarem,Catarina Baptista,Leda Severi,Sheraz Gul,Markus Wolf,Maria Kuzikov,Bernhard Ellinger,Jeanette Reinshagen,Gesa Witt,Pasquale Linciano,Annalisa Tait,Luca Costantino,Rosaria Luciani,Paloma Tejera Nevado,Dorothea Zander-Dinse,Caio H. Franco,Stefania Ferrari,Carolina B. Moraes,Anabela Cordeiro-da-Silva,Glauco Ponterini,Joachim Clos,Jose Maria Alunda,Maria Paola Costi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2019）

Cited 20|Views34
Key words
Leishmaniasis,Flavonoid-like scaffold,Pharmacokinetic studies,Drug resistance,Genomic studies,Fluorescence
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