Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network

Albi Celaj,Marinella Gebbia, Louai Musa,Atina G. Cote,Jamie Snider,Victoria Wong,Minjeong Ko, Tiffany Fong, Paul Bansal,Joseph C. Mellor,Gireesh Seesankar,Maria Nguyen,Shijie Zhou,Liangxi Wang,Nishka Kishore,Igor Stagljar,Yo Suzuki,Nozomu Yachie,Frederick P. Roth

Cell Systems（2019）

引用 18|浏览56

关键词

high-order genetic interactions,genotype-to-phenotype modeling,genetic modeling,interpretable neural network,visible neural network,combinatorial genetic analysis,epistasis,drug resistance,drug efflux,ABC transporters

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