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ABCG2 Requires a Single Aromatic Amino Acid to "clamp" Substrates and Inhibitors into the Binding Pocket

Tomoka Gose,Talha Shafi,Yu Fukuda,Sourav Das,Yao Wang,Alice Allcock,Ailsa Gavan McHarg,John Lynch,Taosheng Chen,Ikumi Tamai,Anang Shelat,Robert C. Ford,John D. Schuetz

FASEB JOURNAL（2020）

Cited 27|Views71
Key words
BCRP,cancer,CETSA,drug,thermal shift assay,kinase inhibitor,transporter
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