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Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068

Chaomin Li,Lloyd Franklin,Robbie Chen,Tamera Mack,Michael Humora,Bin Ma,Brian T. Hopkins,John Guzowski,Fengmei Zheng, Michael MacPhee,Yiqing Lin,Steven Ferguson,Daniel Patience,George A. Moniz,William F. Kiesman,Erin M. O'Brien

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2020）

Cited 6|Views31
Key words
process development,BTK inhibitor,amination,urea formation,impurity control,hemiadipate
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