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Patient-specific Alzheimer-like Pathology in Trisomy 21 Cerebral Organoids Reveals BACE2 As a Gene Dose-Sensitive AD Suppressor in Human Brain

Ivan Alić,Pollyanna A. Goh,Aoife Murray,Erik Portelius,Eleni Gkanatsiou,Gillian Gough,Kin Y. Mok,David Koschut,Reinhard Brunmeir,Yee Jie Yeap,Niamh L. O’Brien,Jürgen Groet,Xiaowei Shao,Steven Havlicek,N. Ray Dunn,Hlin Kvartsberg,Gunnar Brinkmalm,Rosalyn Hithersay,Carla Startin,Sarah Hamburg,Margaret Phillips,Konstantin Pervushin,Mark Turmaine,David Wallon,Anne Rovelet-Lecrux,Hilkka Soininen,Emanuela Volpi,Joanne E. Martin,Jia Nee Foo,David L. Becker,Agueda Rostagno,Jorge Ghiso,Željka Krsnik,Goran Šimić,Ivica Kostović,Dinko Mitrečić,Andre Strydom,Paul T. Francis,Kaj Blennow,John Hardy,Henrik Zetterberg,Dean Nižetić

Molecular psychiatry（2020）

Cited 37|Views68
Key words
Diseases,Genetics,Neuroscience,Medicine/Public Health,general,Psychiatry,Neurosciences,Behavioral Sciences,Pharmacotherapy,Biological Psychology
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