Inhibition of the ATR Kinase Enhances 5-FU Sensitivity Independently of Nonhomologous End-Joining and Homologous Recombination Repair Pathways

Soichiro S. Ito,Yosuke Nakagawa,Masaya Matsubayashi,Yoshihiko M. Sakaguchi,Shinko Kobashigawa,Takeshi K. Matsui,Hitoki Nanaura,Mari Nakanishi,Fumika Kitayoshi,Sotaro Kikuchi,Atsuhisa Kajihara,Shigehiro Tamaki,Kazuma Sugie,Genro Kashino,Akihisa Takahashi,Masatoshi Hasegawa,Eiichiro Mori,Tadaaki Kirita

Journal of Biological Chemistry（2020）

Cited 8|Views21

Key words

ATR serine,threonine kinase,5-fluorouracil,cell-cycle checkpoint,DNA double-strand breaks,homologous recombination,BRCA2,cancer,apoptosis,antineoplastic agent,chemotherapy,DNA repair,DNA damage response,cell cycle,anticancer drug

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